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The dermis is the layer of the skin primarily responsible for sensation. This is because it contains a rich network of nerve endings and sensory receptors that detect touch, temperature, pressure, and pain. These receptors send signals to the brain, allowing the body to perceive various sensations. The dermis also contains blood vessels, sweat glands, and hair follicles, which contribute to its overall function and ability to communicate sensory information.

The stratum lucidum and stratum corneum are both layers of the epidermis, which is the outermost part of the skin and provides a protective barrier. While these layers help in protecting the body, they are not directly involved in sensation. The stratum basale, on the other hand, is the deepest layer of the epidermis where the production of new skin cells occurs. While it contains some sensory nerve endings, it is not the primary layer associated with sensory functions compared to the dermis. Thus, the dermis is the correct answer for its key role in sensation.